After graduating, Anne Will worked for Sender Freies Berlin, and from 1991 to 1992 she did a traineeship in radio and television. From 1996 to 1998 she hosted the WDR media show Parlazzo. From November 1999 she was the first woman to present the sports show, which had previously been dominated by men, which suddenly made her known to a large audience. In 2000 she moderated for the ARD
Sports broadcasts of the Olympic Games from Sydney.
As the successor to Gabi Bauer, Will took up her new position on April 14, 2001 as moderator of the
Topics of the day, initially alternating with Ulrich
Wickert, alternating with his successor Tom Buhrow from September 2006. She hosted her last show on June 24, 2007; then she was replaced by Caren Miosga.

After Günther Jauch had rejected the offered position, the directors of ARD chose Anne Will to succeed Sabine Christiansen for a political talk show that was first broadcast on September 16, 2007 under the name "Anne Will" and has since been broadcast on Sunday evening has its place at the scene of the crime.